The global functional food market sees surging demand for egg yolk peptide, a high-value active ingredient widely used in health supplements, sports nutrition and infant auxiliary food. Traditional solid-liquid separation methods such as plate-frame filtration and static sedimentation fail to separate egg residue, protein hydrolysate and impurity sediment efficiently, featuring low peptide recovery, long processing time and frequent filter material replacement. Horizontal decanter centrifuges rely on continuous differential speed centrifugal separation to separate solid egg residues and liquid peptide stock solution in one sealed step under low-temperature mild conditions. This paper illustrates the working principle, structural features, complete technological flow and multi-scenario application value of food-grade horizontal decanter centrifuges in egg yolk peptide processing. Compared with conventional separation equipment, the decanter centrifuge delivers continuous automatic opera