Fermentation broth processing is a core procedure in bio-fermentation, enzyme preparation, food additive and functional ingredient production. Fermented crude liquid contains complex impurities including microbial cells, cell debris, residual culture medium, protein colloids and insoluble suspended solids. Traditional clarification methods such as frame filtration, static sedimentation and vacuum filtration have obvious defects, including low separation efficiency, long production cycle, large consumable loss and inevitable active ingredient loss. Sanitary disc stack centrifugal separation technology realizes high-speed solid-liquid separation relying on density difference under fully enclosed low-temperature conditions. It continuously removes microbial residues and macromolecular colloidal impurities without damaging bioactive substances, significantly improving filtrate clarity, reducing downstream membrane fouling pressure and improving product yield. This stable and efficient phys