Glucosamine hydrochloride, as a health-care pharmaceutical, plays an excellent role in protecting joints. A mature production process for glucosamine hydrochloride is fermentation. In the fermentation process, the fermentation broth has a complex composition, containing a large amount of culture medium, mycelia, miscellaneous proteins, pigments and other impurities. To separate and purify glucosamine hydrochloride, various processes need to be combined.
Chengdu HeCheng Filtration Technology Co., Ltd. has developed a set of membrane separation processes for glucosamine hydrochloride impurity removal and concentration based on the material properties of glucosamine hydrochloride and the application characteristics of membrane separation technology, which improves product quality, reduces energy consumption, and saves production costs.
Brief Introduction to Membrane-based Impurity Removal and Concentration Process for Glucosamine Hydrochloride Fermentation broth → Ceramic membrane separation system → Low-pressure membrane concentration system → Medium-pressure membrane concentration system → MVR/multi-effect thermal concentration → Subsequent processes
The concentrated solution after ceramic membrane separation is subjected to plate-and-frame filtration. The filter cake, consisting of bacterial cells and culture medium residues, can be used as feed.
The low-pressure membrane concentration system increases the concentration of glucosamine hydrochloride to 50g/L.
The medium-pressure membrane concentration system increases the concentration of glucosamine hydrochloride to more than 100g/L.
The permeate from the two-stage concentration is reused in the previous extraction process, with the glucosamine content in the permeate being less than 0.2g/L.
MVR has much lower energy consumption than traditional thermal concentration. It uses a steam compressor to compress steam, improving steam utilization and saving a large amount of steam.
Technical Features of Membrane Separation System Equipment
Advanced nanoscale membrane separation elements enable selective separation and concentration at the molecular level.
Unique cross-flow operation process solves the problem of easy clogging of filtration and separation elements.
Reduces solvent consumption, saves energy, reduces emissions, and complies with national environmental protection policies.
Concentrates at room or low temperature without damaging heat-sensitive components; the concentration process can remove inorganic salts, reduce the ash content of the final product, and improve product quality.
Pure physical separation process without adding chemical agents or auxiliaries.
Simplifies the production process, shortens the production cycle, and improves production efficiency and yield.
Membrane modular design can be directly integrated into the original process, with easy replacement of membrane modules.
Automatic program control and online cleaning, maintenance, reducing workload and improving production efficiency.
The membrane concentration permeate can be reused in the extraction section, reducing water usage and wastewater discharge, alleviating the enterprise's environmental burden, and complying with national environmental protection policies.
Membrane separation technology is a kind of technology that uses a selectively permeable membrane as the separation medium. By applying a certain driving force (such as pressure difference, concentration difference, etc.) on both sides of the membrane, the components on the feed side can selectively permeate through the membrane, so as to achieve the purposes of separation, purification, concentration and so on.
Nowadays, more and more enterprises have keenly perceived the remarkable advantages brought by membrane technology and are actively adopting this technology to boost their own development.
In the food and beverage industry, enterprises utilize membrane technology for operations such as juice concentration and protein purification. This not only effectively preserves the flavor and nutritional components of products but also enhances product quality and extends the shelf life.
In the chemical industry, membrane technology can be applied to the recovery and separation of solvents. It improves the utilization rate of raw materials, reduces production costs, and at the same time, decreases pollutant emissions, enabling green production.
In the water treatment industry, membrane technology plays an irreplaceable role. From the in-depth treatment of industrial wastewater to the purification of drinking water, by removing impurities, heavy metal ions, and microorganisms in water, it provides enterprises with high-quality production water and effluent that meets the standards.
In the biopharmaceutical industry, membrane separation technology can accurately separate and purify biological products, ensuring the activity and purity of products and facilitating the smooth progress of new drug research and development as well as production.
It can be said that membrane technology is gradually becoming an important means for enterprises to enhance their competitiveness and achieve sustainable development.
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